Tacrolimus is a calcineurin inhibitor primarily used for treatment of transplant patients. The strong immunosuppressive properties of the drug have led to its prominent position in the pharmacological treatment of transplant patients. The pharmacokinetics of the drug are under influence of a large series of factors ranging from genetic factors to factors as diet, age, gender, transplanted organ and other drugs. These complex pharmacokinetics make frequent therapeutic drug monitoring obligatory. Therapeutic drug monitoring has therefore obtained an important place in the treatment of transplant patients on Tacrolimus.
Monitoring of Tacrolimus with the easy and friendly DBS method makes it possible to perform therapeutic drug monitoring at any moment and at any place. The regular therapeutic drug monitoring often consists of a fasting blood test taken early in the morning. DBS allows the patient to perform the blood sampling at ease at home before breakfast and send the blood sample by post to DBSL for analysis. DBSL will inform her/him on the receipt of the blood sample. The physician will receive the measured blood drug level in due course. DBSL makes use of state of the art LC-MS/MS technology to assess the Tacrolimus blood level.